Brice Lagrange

Associate Professor

7. Biosciences, Technologies and Ethics

Campus Lyon - Saint Paul
10 Place des archives 69002 Lyon

Further information

  • Field (CNU): 64. Biochemistry and Molecular Biology

Research areas

Cell Biology

Teaching areas

Immunology Physiology
  • Chapters
    • Book chapters
      • WALLET, Pierre, LAGRANGE, Brice, HENRY, Thomas (2016). «Francisella Inflammasomes: Integrated Responses to a Cytosolic Stealth Bacterium». In : Steffen Backert (dir.), Inflammasome Signaling and Bacterial Infections, coll. Current Topics in Microbiology and Immunology. Springer Publishing, 229-256. URL/DOI :  [+]
  • Articles
    • Articles in peer-reviewed journals
      • NIU, Tingting, DE ROSNY, Charlotte, CHAUTARD, Séverine, REY, Amaury, PATOLI, Danish, GROSLAMBERT, Marine, COSSON, Camille, LAGRANGE, Brice, ZHANG, Zhirong, VISVIKIS, Orane, HACOT, Sabine, HOLOGNE, Maggy, WALKER, Olivier, WONG, Jeimin, WANG, Ping, RICCI, Roméo, HENRY, Thomas, BOYER, Laurent, PETRILLI, Virginie, PY, Bénédicte F. (2021). «NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly». Nature Communications, 12, 1. URL/DOI :  [+]
      • WANDEL, Michal P., KIM, Bae-Hoon, PARK, Eui-Soon, BOYLE, Keith B., NAYAK, Komal, LAGRANGE, Brice, HEROD, Adrian, HENRY, Thomas, ZILBAUER, Matthias, ROHDE, John, MACMICKING, John D., RANDOW, Felix (2020). «Guanylate-binding proteins convert cytosolic bacteria into caspase-4 signaling platforms». Nature immunology, 21, 8, 880-891. URL/DOI :  [+]
      • EREN, Elif, PLANÈS, Rémi, BAGAYOKO, Salimata, BORDIGNON, Pierre-Jean, CHAOUI, Karima, HESSEL, Audrey, SANTONI, Karin, PINILLA, Miriam, LAGRANGE, Brice, BURLET-SCHILTZ, Odile, HOWARD, Jonathan C, HENRY, Thomas, YAMAMOTO, Masahiro, MEUNIER, Etienne (2020). «Irgm2 and Gate-16 cooperatively dampen Gram-negative bacteria-induced caspase-11 response». EMBO reports, 21, 11, e50829. URL/DOI :  [+]
      • BENAOUDIA, Sacha, MARTIN, Amandine, PUIG GAMEZ, Marta, GAY, Gabrielle, LAGRANGE, Brice, CORNUT, Maxence, KRASNYKOV, Kyrylo, CLAUDE, Jean-Baptiste, BOURGEOIS, Cyril F, HUGHES, Sandrine, GILLET, Benjamin, ALLATIF, Omran, CORBIN, Antoine, RICCI, Romeo, HENRY, Thomas (2019). «A genome-wide screen identifies IRF2 as a key regulator of caspase-4 in human cells». EMBO reports, 20, 9, e48235. URL/DOI :  [+]
      • LAGRANGE, Brice, BENAOUDIA, Sacha, WALLET, Pierre, MAGNOTTI, Flora, PROVOST, Angelina, MICHAL, Fanny, MARTIN, Amandine, DI LORENZO, Flaviana, PY, Bénédicte F., MOLINARO, Antonio, HENRY, Thomas (2018). «Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11». Nature Communications, 9, 1, art. 242. URL/DOI :  [+]
      • JAMILLOUX, Yvan, LAGRANGE, Brice, DI MICCO, Antonia, BOURDONNAY, Emilie, PROVOST, Angélina, TALLANT, Rémy, HENRY, Thomas, MARTINON, Fabio (2018). «A proximity-dependent biotinylation (BioID) approach flags the p62/sequestosome-1 protein as a caspase-1 substrate». Journal of Biological Chemistry, 293, 32, 12563-12575. URL/DOI :  [+]
      • SANTOS, José Carlos, DICK, Mathias S, LAGRANGE, Brice, DEGRANDI, Daniel, PFEFFER, Klaus, YAMAMOTO, Masahiro, MEUNIER, Etienne, PELCZAR, Pawel, HENRY, Thomas, BROZ, Petr (2018). «targets host guanylate-binding proteins to the bacterial outer membrane for non-canonical inflammasome activation». The EMBO Journal, 37, 6. URL/DOI :  [+]
      • WALLET, Pierre, BENAOUDIA, Sacha, MOSNIER, Amandine, LAGRANGE, Brice, MARTIN, Amandine, LINDGREN, Helena, GOLOVLIOV, Igor, MICHAL, Fanny, BASSO, Pauline, DJEBALI, Sophia, PROVOST, Angelina, ALLATIF, Omran, MEUNIER, Etienne, BROZ, Petr, YAMAMOTO, Masahiro, PY, Bénédicte F., FAUDRY, Eric, SJÖSTEDT, Anders, HENRY, Thomas (2017). «IFN-? extends the immune functions of Guanylate Binding Proteins to inflammasome-independent antibacterial activities during Francisella novicida infection». PLoS Pathogens, 13, 10, e1006630. URL/DOI :  [+]
      • BOXIO, Rachel, WARTELLE, Julien, NAWROCKI-RABY, Béatrice, LAGRANGE, Brice, MALLERET, Laurette, HIRCHE, Timothee, TAGGART, Clifford, PACHECO, Yves, DEVOUASSOUX, Gilles, BENTAHER, Abderrazzaq (2016). «Neutrophil elastase cleaves epithelial cadherin in acutely injured lung epithelium». Respiratory research, 17, 1, art. 129. URL/DOI :  [+]
      • WALLET, Pierre, LAGRANGE, Brice, HENRY, Thomas (2015). «Les guanylate binding proteins : de nouveaux acteurs de l’immunité antibactérienne du cytosol des cellules hôtes». Médecine sciences (M/S), 31, 6-7, 600-603. URL/DOI :  [+]
      • LARGEOT, Anne, PAGGETTI, Jérôme, BROSÉUS, Julien, AUCAGNE, Romain, LAGRANGE, Brice, MARTIN, Romain Z., BERTHELET, Jean, QUÉRÉ, Ronan, LUCCHI, Géraldine, DUCOROY, Patrick, BASTIE, Jean-Noël, DELVA, Laurent (2013). «Symplekin, a polyadenylation factor, prevents MOZ and MLL activity on HOXA9 in hematopoietic cells». Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1833, 12, 3054-3063. URL/DOI :  [+]
      • LAGRANGE, Brice, MARTIN, Romain Z., DROIN, Nathalie, AUCAGNE, Romain, PAGGETTI, Jérôme, LARGEOT, Anne, ITZYKSON, Raphaël, SOLARY, Eric, DELVA, Laurent, BASTIE, Jean-Noël (2013). «A role for miR-142-3p in colony-stimulating factor 1-induced monocyte differentiation into macrophages». Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1833, 8, 1936-1946. URL/DOI :  [+]
      • LAGRANGE, Brice, MARTIN, Romain Z., DROIN, Nathalie, SOLARY, Éric, BASTIE, Jean-Noël, DELVA, Laurent (2013). «MiR-142-3p et leucémogenèse». Médecine sciences (M/S), 29, 6-7, 574-576. URL/DOI :  [+]
      • CARTIER, Jessy, BERTHELET, Jean, MARIVIN, Arthur, GEMBLE, Simon, EDMOND, Valérie, PLENCHETTE, Stéphanie, LAGRANGE, Brice, HAMMANN, Arlette, DUPOUX, Alban, DELVA, Laurent, EYMIN, Béatrice, SOLARY, Eric, DUBREZ, Laurence (2011). «Cellular Inhibitor of Apoptosis Protein-1 (cIAP1) Can Regulate E2F1 Transcription Factor-mediated Control of Cyclin Transcription». Journal of Biological Chemistry, 286, 30, 26406-26417. URL/DOI :  [+]
      • AUCAGNE, Romain, DROIN, Nathalie, PAGGETTI, Jérôme, LAGRANGE, Brice, LARGEOT, Anne, HAMMANN, Arlette, BATAILLE, Amandine, MARTIN, Laurent, YAN, Kai-Ping, FENAUX, Pierre, LOSSON, Régine, SOLARY, Eric, BASTIE, Jean-Noël, DELVA, Laurent (2011). «Transcription intermediary factor 1? is a tumor suppressor in mouse and human chronic myelomonocytic leukemia». The Journal of Clinical Investigation, 121, 6, 2361-2370. URL/DOI :  [+]
      • PAGGETTI, J, LARGEOT, A, AUCAGNE, R, JACQUEL, A, LAGRANGE, Brice, YANG, X-J, SOLARY, E, BASTIE, J-N, DELVA, L (2010). «Crosstalk between leukemia-associated proteins MOZ and MLL regulates HOX gene expression in human cord blood CD34+ cells». Oncogene, 29, 36, 5019-5031. URL/DOI :  [+]
  • Academic background
    • 2011 PhD in Life Sciences, Université de Bourgogne, France
  • Teachings
    • Since 2020 Innate immunity, Lyon Catholic University, France
    • Since 2019 Immunologie, Lyon Catholic University, France
    • Since 2019 Immunology, Lyon Catholic University, France
    • Since 2019 Physiologie et Biologie Humaine, Lyon Catholic University, France
  • Languages
    • English