Brice Lagrange

Associate Professor at UCLy

7. Biosciences, Technologies and Ethics

Campus Lyon - Saint Paul
10 Place des archives 69002 Lyon


  • Member of Biosciences, technologies, ethics research team, UR CONFLUENCE : Sciences et Humanités (EA 1598) Lyon Catholic University
  • Teacher-researcher, ESTBB Lyon Catholic University

Further information

Research areas

Cell Biology

Teaching areas

Immunology Physiology


Brice Lagrange holds a PhD in Molecular and Cellular Biology from the University of Burgundy. He is a teacher-researcher in cell biology and immunology at the CONFLUENCE: Sciences et Humanités research unit at the Catholic University of Lyon. His work focuses on understanding the molecular mechanisms induced by the cytokine IFN-g at the origin of tumour cell death. He also teaches immunology and human physiology at ESTBB.
  • Chapters
    • Book chapters
      • WALLET, Pierre, LAGRANGE, Brice, HENRY, Thomas (2016). «Francisella Inflammasomes: Integrated Responses to a Cytosolic Stealth Bacterium». In : Steffen Backert (dir.), Inflammasome Signaling and Bacterial Infections, coll. Current Topics in Microbiology and Immunology. Springer Publishing, 229-256.  [+]
  • Articles
    • Articles in peer-reviewed journals
      • VALEVA, Stanimira V, DEGABRIEL, Manon, MICHAL, Fanny, GAY, Gabrielle, ROHDE, John R, RANDOW, Felix, LAGRANGE, Brice, HENRY, Thomas (2023). «Comparative study of GBP recruitment on two cytosol-dwelling pathogens, and highlights differences in GBP repertoire and in GBP1 motif requirements». Foodborne pathogens and disease, 81, ftad005.  [+]
      • NIU, Tingting, DE ROSNY, Charlotte, CHAUTARD, Séverine, REY, Amaury, PATOLI, Danish, GROSLAMBERT, Marine, COSSON, Camille, LAGRANGE, Brice, ZHANG, Zhirong, VISVIKIS, Orane, HACOT, Sabine, HOLOGNE, Maggy, WALKER, Olivier, WONG, Jeimin, WANG, Ping, RICCI, Roméo, HENRY, Thomas, BOYER, Laurent, PETRILLI, Virginie, PY, Bénédicte F. (2021). «NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly». Nature Communications, 12, 1.  [+]
      • WANDEL, Michal P., KIM, Bae-Hoon, PARK, Eui-Soon, BOYLE, Keith B., NAYAK, Komal, LAGRANGE, Brice, HEROD, Adrian, HENRY, Thomas, ZILBAUER, Matthias, ROHDE, John, MACMICKING, John D., RANDOW, Felix (2020). «Guanylate-binding proteins convert cytosolic bacteria into caspase-4 signaling platforms». Nature immunology, 21, 8, 880-891.  [+]
      • EREN, Elif, PLANÈS, Rémi, BAGAYOKO, Salimata, BORDIGNON, Pierre-Jean, CHAOUI, Karima, HESSEL, Audrey, SANTONI, Karin, PINILLA, Miriam, LAGRANGE, Brice, BURLET-SCHILTZ, Odile, HOWARD, Jonathan C, HENRY, Thomas, YAMAMOTO, Masahiro, MEUNIER, Etienne (2020). «Irgm2 and Gate-16 cooperatively dampen Gram-negative bacteria-induced caspase-11 response». EMBO reports, 21, 11, e50829.  [+]
      • BENAOUDIA, Sacha, MARTIN, Amandine, PUIG GAMEZ, Marta, GAY, Gabrielle, LAGRANGE, Brice, CORNUT, Maxence, KRASNYKOV, Kyrylo, CLAUDE, Jean-Baptiste, BOURGEOIS, Cyril F, HUGHES, Sandrine, GILLET, Benjamin, ALLATIF, Omran, CORBIN, Antoine, RICCI, Romeo, HENRY, Thomas (2019). «A genome-wide screen identifies IRF2 as a key regulator of caspase-4 in human cells». EMBO reports, 20, 9, e48235.  [+]
      • LAGRANGE, Brice, BENAOUDIA, Sacha, WALLET, Pierre, MAGNOTTI, Flora, PROVOST, Angelina, MICHAL, Fanny, MARTIN, Amandine, DI LORENZO, Flaviana, PY, Bénédicte F., MOLINARO, Antonio, HENRY, Thomas (2018). «Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11». Nature Communications, 9, 1, art. 242.  [+]
      • JAMILLOUX, Yvan, LAGRANGE, Brice, DI MICCO, Antonia, BOURDONNAY, Emilie, PROVOST, Angélina, TALLANT, Rémy, HENRY, Thomas, MARTINON, Fabio (2018). «A proximity-dependent biotinylation (BioID) approach flags the p62/sequestosome-1 protein as a caspase-1 substrate». Journal of Biological Chemistry, 293, 32, 12563-12575.  [+]
      • SANTOS, José Carlos, DICK, Mathias S, LAGRANGE, Brice, DEGRANDI, Daniel, PFEFFER, Klaus, YAMAMOTO, Masahiro, MEUNIER, Etienne, PELCZAR, Pawel, HENRY, Thomas, BROZ, Petr (2018). «targets host guanylate-binding proteins to the bacterial outer membrane for non-canonical inflammasome activation». The EMBO Journal, 37, 6.  [+]
      • WALLET, Pierre, MONACK, Denise M., BENAOUDIA, Sacha, MOSNIER, Amandine, LAGRANGE, Brice, MARTIN, Amandine, LINDGREN, Helena, GOLOVLIOV, Igor, MICHAL, Fanny, BASSO, Pauline, DJEBALI, Sophia, PROVOST, Angelina, ALLATIF, Omran, MEUNIER, Etienne, BROZ, Petr, YAMAMOTO, Masahiro, PY, Bénédicte F., FAUDRY, Eric, SJÖSTEDT, Anders, HENRY, Thomas (2017). «IFN-? extends the immune functions of Guanylate Binding Proteins to inflammasome-independent antibacterial activities during Francisella novicida infection». PLoS Pathogens, 13, 10, e1006630.  [+]
      • BOXIO, Rachel, WARTELLE, Julien, NAWROCKI-RABY, Béatrice, LAGRANGE, Brice, MALLERET, Laurette, HIRCHE, Timothee, TAGGART, Clifford, PACHECO, Yves, DEVOUASSOUX, Gilles, BENTAHER, Abderrazzaq (2016). «Neutrophil elastase cleaves epithelial cadherin in acutely injured lung epithelium». Respiratory research, 17, 1, art. 129.  [+]
      • WALLET, Pierre, LAGRANGE, Brice, HENRY, Thomas (2015). «Les guanylate binding proteins : de nouveaux acteurs de l’immunité antibactérienne du cytosol des cellules hôtes». Médecine sciences (M/S), 31, 6-7, 600-603.  [+]
      • LARGEOT, Anne, PAGGETTI, Jérôme, BROSÉUS, Julien, AUCAGNE, Romain, LAGRANGE, Brice, MARTIN, Romain Z., BERTHELET, Jean, QUÉRÉ, Ronan, LUCCHI, Géraldine, DUCOROY, Patrick, BASTIE, Jean-Noël, DELVA, Laurent (2013). «Symplekin, a polyadenylation factor, prevents MOZ and MLL activity on HOXA9 in hematopoietic cells». Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1833, 12, 3054-3063.  [+]
      • LAGRANGE, Brice, MARTIN, Romain Z., DROIN, Nathalie, AUCAGNE, Romain, PAGGETTI, Jérôme, LARGEOT, Anne, ITZYKSON, Raphaël, SOLARY, Eric, DELVA, Laurent, BASTIE, Jean-Noël (2013). «A role for miR-142-3p in colony-stimulating factor 1-induced monocyte differentiation into macrophages». Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1833, 8, 1936-1946.  [+]
      • LAGRANGE, Brice, MARTIN, Romain Z., DROIN, Nathalie, SOLARY, Éric, BASTIE, Jean-Noël, DELVA, Laurent (2013). «MiR-142-3p et leucémogenèse». Médecine sciences (M/S), 29, 6-7, 574-576.  [+]
      • CARTIER, Jessy, BERTHELET, Jean, MARIVIN, Arthur, GEMBLE, Simon, EDMOND, Valérie, PLENCHETTE, Stéphanie, LAGRANGE, Brice, HAMMANN, Arlette, DUPOUX, Alban, DELVA, Laurent, EYMIN, Béatrice, SOLARY, Eric, DUBREZ, Laurence (2011). «Cellular Inhibitor of Apoptosis Protein-1 (cIAP1) Can Regulate E2F1 Transcription Factor-mediated Control of Cyclin Transcription». Journal of Biological Chemistry, 286, 30, 26406-26417.  [+]
      • AUCAGNE, Romain, DROIN, Nathalie, PAGGETTI, Jérôme, LAGRANGE, Brice, LARGEOT, Anne, HAMMANN, Arlette, BATAILLE, Amandine, MARTIN, Laurent, YAN, Kai-Ping, FENAUX, Pierre, LOSSON, Régine, SOLARY, Eric, BASTIE, Jean-Noël, DELVA, Laurent (2011). «Transcription intermediary factor 1? is a tumor suppressor in mouse and human chronic myelomonocytic leukemia». The Journal of Clinical Investigation, 121, 6, 2361-2370.  [+]
      • PAGGETTI, J, LARGEOT, A, AUCAGNE, R, JACQUEL, A, LAGRANGE, Brice, YANG, X-J, SOLARY, E, BASTIE, J-N, DELVA, L (2010). «Crosstalk between leukemia-associated proteins MOZ and MLL regulates HOX gene expression in human cord blood CD34+ cells». Oncogene, 29, 36, 5019-5031.  [+]
    • Review articles
      • HILLAIRE, Marine, LAWRENCE, Philip, LAGRANGE, Brice (2023). «IFN-γ: A Crucial Player in the Fight Against HBV Infection?». Immune Network, 23, 4, e30.  [+]
  • Communications (conferences, seminars, study days)
    • LAGRANGE, Brice (2023). «Effect of IFN-γ alone and in combination with chemotherapeutic drugs on the induction of cell death in the lymphoma cell line U937.». Innate Sensors and Inflammation Meeting, Innate Sensors Community (InnaSCo), FrontInov, ENS, September 2023, Lyon, France.  [+]
  • Academic background
    • 2011 PhD in Life Sciences, Université de Bourgogne, France
  • Educational responsibilities and professional experiences
    • Since 2019 Teacher-researcher, ESTBB, Lyon Catholic University, France
  • Teachings
    • Since 2020 Innate immunity, Lyon Catholic University, France
    • Since 2019 Immunologie, Lyon Catholic University, France
    • Since 2019 Immunology, Lyon Catholic University, France
    • Since 2019 Physiologie et Biologie Humaine, Lyon Catholic University, France
  • Languages
    • English