Back to the list

Marine Croze

Associate Professor at UCLy

Research group (7) Biotechnologies, health and ethics

mcroze@univ-catholyon.fr

Campus Lyon - Saint Paul
10 Place des archives 69002 Lyon

Function

  • Member of the Research group (7) Biotechnologies, health and ethics, UR CONFLUENCE : Sciences et Humanités (EA1598) Lyon Catholic University

Further information

  • CNU section: 65. Cellular Biology

Research areas

Biologie Sciences du vivant Cancer Maladies Métaboliques Cellular Stresses

Teaching areas

Genomic Genetic Engineering Biologie Cellulaire Chronic Diseases Scientific Writing and Critical Literature Review

Presentation

Assistant Professor / Researcher in Cell and Molecular Biology, with an engineering degree and a PhD from INSA Lyon.
My PhD, carried out at the CarMeN laboratory (Lyon), focused on a nutritional strategy to prevent type 2 diabetes and obesity. In parallel, I contributed to several projects aimed at understanding the molecular mechanisms of insulin resistance in muscle and adipose tissue, particularly in relation to ozone air pollution, lipid peroxidation derivatives, and specific uremic toxins.
I then developed expertise in Neuroscience as a teaching and research fellow (ATER) at the Faculty of Pharmacy of Lyon 1, within the BioRaN team, working on the effects of ozone pollution on the brain and on Alzheimer’s disease.
A postdoctoral fellowship in Dr. Poitout’s laboratory (Montreal) enabled me to extend my expertise to the pancreatic side of diabetes through the study of insulin secretion and of glucagon- and somatostatin-producing alpha and delta pancreatic cells.
I am currently an Assistant Professor at ESTBB, within Research Unit Group 7, where I collaborate with Axis 3 on a drug-design project aimed at identifying novel therapeutic molecules for hepatocellular carcinoma or other chronic diseases that share similar pathogenic mechanisms, including diabetes and neurodegenerative disorders.
  • Scientific Publications & Communications
    • Articles In Peer-Reviewed Journals
      • KOPPE, Laetitia, CROZE, Marine, MONTEIRO, Elisa B., BENOIT, Bérengère, BRES, Emilie, GUEBRE-EGZIABHER, Fitsum, DALEPRANE, Julio B., FOUQUE, Denis, SOULAGE, Christophe O. (2021). «The protein-bound uremic toxin p-cresyl-sulfate promotes intracellular ROS production and lipid peroxidation in 3T3-L1 adipose cells». Biochimie, 189, 137-143. [+]
      • CROZE, Marine, FLISHER, Marcus F., GUILLAUME, Arthur, TREMBLAY, Caroline, NOGUCHI, Glyn M., GRANZIERA, Sabrina, VIVOT, Kevin, CASTILLO, Vincent C., CAMPBELL, Scott A., GHISLAIN, Julien, HUISING, Mark O., POITOUT, Vincent (2021). «Free fatty acid receptor 4 inhibitory signaling in delta cells regulates islet hormone secretion in mice». Molecular Metabolism, 45, 101166. [+]
      • CROZE, Marine, GUILLAUME, Arthur, ETHIER, Mélanie, FERGUSSON, Grace, TREMBLAY, Caroline, CAMPBELL, Scott A, MAACHI, Hasna, GHISLAIN, Julien, POITOUT, Vincent (2021). «Combined Deletion of Free Fatty-Acid Receptors 1 and 4 Minimally Impacts Glucose Homeostasis in Mice». Endocrinology, 162, 3. [+]
      • SOULÈRE, Laurent, ALIX, Pascaline M., CROZE, Marine, SOULAGE, Christophe O. (2018). «Identification of novel antilipogenic agents targeting fatty acid biosynthesis through structure-based virtual screening». Chemical Biology and Drug Design, 92, 1, 1366-1372. [+]
      • CROZE, Marine, ZIMMER, Luc (2018). «Ozone Atmospheric Pollution and Alzheimer’s Disease: From Epidemiological Facts to Molecular Mechanisms». Journal of Alzheimer's Disease, 62, 2, 503-522. [+]
      • KOPPE, Laetitia, ALIX, Pascaline M, CROZE, Marine, CHAMBERT, Stéphane, VANHOLDER, Raymond, GLORIEUX, Griet, FOUQUE, Denis, SOULAGE, Christophe O (2017). «p-Cresyl glucuronide is a major metabolite of p-cresol in mouse: in contrast to p-cresyl sulphate, p-cresyl glucuronide fails to promote insulin resistance». Nephrology Dialysis Transplantation, 32, 12, 2000-2009. [+]
      • CROZE, Marine, GÉLOËN, Alain, SOULAGE, Christophe O. (2015). «Abnormalities in myo-inositol metabolism associated with type 2 diabetes in mice fed a high-fat diet: benefits of a dietary myo-inositol supplementation». British journal of nutrition (The), 113, 12, 1862-1875. [+]
      • VELLA, Roxane E., PILLON, Nicolas J., ZARROUKI, Bader, CROZE, Marine, KOPPE, Laetitia, GUICHARDANT, Michel, PESENTI, Sandra, CHAUVIN, Marie-Agnès, RIEUSSET, Jennifer, GÉLOËN, Alain, SOULAGE, Christophe O. (2015). «Ozone Exposure Triggers Insulin Resistance Through Muscle c-Jun N-Terminal Kinase Activation». Diabetes, 64, 3, 1011-1024. [+]
      • STOCKLER-PINTO, Milena Barcza, FOUQUE, Denis, SOULAGE, Christophe O., CROZE, Marine, MAFRA, Denise (2014). «Indoxyl Sulfate and p-Cresyl Sulfate in Chronic Kidney Disease. Could These Toxins Modulate the Antioxidant Nrf2-Keap1 Pathway?». Journal of Renal Nutrition, 24, 5, 286-291. [+]
      • PELLETIER, Caroline C., KOPPE, Laetitia, ALIX, Pascaline M., KALBACHER, Emilie, CROZE, Marine, HADJ-AISSA, Aoumeur, FOUQUE, Denis, GUEBRE-EGZIABHER, Fitsum, SOULAGE, Christophe O. (2014). «The Relationship between Renal Function and Plasma Concentration of the Cachectic Factor Zinc-Alpha2-Glycoprotein (ZAG) in Adult Patients with Chronic Kidney Disease». PLoS ONE, 9, 7, e103475. [+]
      • CROZE, Marine, SOULAGE, Christophe O. (2013). «Potential role and therapeutic interests of myo-inositol in metabolic diseases». Biochimie, 95, 10, 1811-1827. [+]
      • PELLETIER, Caroline C., KOPPE, Laetitia, CROZE, Marine, KALBACHER, Emilie, VELLA, Roxane E., GUEBRE-EGZIABHER, Fitsum, GÉLOËN, Alain, BADET, Lionel, FOUQUE, Denis, SOULAGE, Christophe O. (2013). «White adipose tissue overproduces the lipid-mobilizing factor zinc a2-glycoprotein in chronic kidney disease». Kidney international, 83, 5, 878-886. [+]
      • CROZE, Marine, VELLA, Roxane E., PILLON, Nicolas J., SOULA, Hédi A., HADJI, Lilas, GUICHARDANT, Michel, SOULAGE, Christophe O. (2013). «Chronic treatment with myo-inositol reduces white adipose tissue accretion and improves insulin sensitivity in female mice». The Journal of Nutritional Biochemistry, 24, 2, 457-466. [+]
      • KOPPE, Laetitia, PILLON, Nicolas J., VELLA, Roxane E., CROZE, Marine, PELLETIER, Caroline C., CHAMBERT, Stéphane, MASSY, Ziad, GLORIEUX, Griet, VANHOLDER, Raymond, DUGENET, Yann, SOULA, Hédi A., FOUQUE, Denis, SOULAGE, Christophe O. (2013). «p-Cresyl Sulfate Promotes Insulin Resistance Associated with CKD». Journal of the American Society of Nephrology, 24, 1, 88-99. [+]
      • PILLON, Nicolas J., CROZE, Marine, VELLA, Roxane E., SOULÈRE, Laurent, LAGARDE, Michel, SOULAGE, Christophe O. (2012). «The Lipid Peroxidation By-Product 4-Hydroxy-2-Nonenal (4-HNE) Induces Insulin Resistance in Skeletal Muscle through Both Carbonyl and Oxidative Stress». Endocrinology, 153, 5, 2099-2111. [+]
      • PILLON, Nicolas J., SOULÈRE, Laurent, VELLA, Roxane E., CROZE, Marine, CARÉ, Bertrand R., SOULA, Hedi A., DOUTHEAU, Alain, LAGARDE, Michel, SOULAGE, Christophe O. (2010). «Quantitative structure–activity relationship for 4-hydroxy-2-alkenal induced cytotoxicity in L6 muscle cells». Chemico-Biological Interactions, 188, 1, 171-180. [+]
  • Scientific Collaborations
    • Member of research laboratories
      • Since 2021, Member of the Research group (7) Biotechnologies, health and ethics, UR CONFLUENCE : Sciences et Humanités (EA1598), UCLy, France
    • Involvement in scientific groups and learned societies
      • 2017 - 2019, Boston Ithaca Islet Club (BIIC) Membership
      • 2017 - 2019, Membre du CMDO
      • 2016 - 2021, SFD membership
      • 2016 - 2019, Montreal Diabetes Research Center (MDRC) membership
  • Research Evaluation Activities
    • Reviewer of Scientific Publications
      • 2025 : Scientific Reports Publication Reviewing activity, Scientific Reports
      • 2023 : Scientific Reports publication reviewing activity, Scientific Reports
      • 2022 : Frontiers in Endocrinology publication review, Frontiers in Endocrinology
      • 2018 : Clinical Nutrition publication reviewing activity, Clinical Nutrition
      • 2017 : JLR publication review, Journal of Lipid Research
  • Diplomas
    • 2013, Doctorat en Biochimie, Etude du potentiel insulino-sensibilisant du myo-inositol chez la souris : Evaluation de l’intérêt nutritionnel d’une supplémentation en myo-inositol, INSA Lyon, France
    • 2010, Diplôme d’ingénieur en Biochimie et Biotechnologies, INSA Lyon, France
    • 2010, Master Recherche en Physiologie et Neurosciences, Université Claude Bernard Lyon 1, France
  • Research professional experiences
    • 2016 - 2020, Postdoctoral researcher at Poitout Lab, Centre de recherche du Centre hospitalier de l’Université de Montréal - CRCHUM, Canada
  • Pedagogical activities and responsabilities
    • 2013 - 2015 Teaching Assistant, Université Claude Bernard Lyon 1, France
    • Teaching
      • 2023 - 2025, Critical Literature Review, Lyon Catholic University, France
      • 2023 - 2025, "Chronic Diseases" Elective module, Lyon Catholic University, France
      • 2022 - 2025, Scientific Communication, Lyon Catholic University, France
      • 2022 - 2025, Cell Culture, Lyon Catholic University, France
      • 2021 - 2025, Genetic Engineering, Lyon Catholic University, France
      • 2021 - 2025, Structural & Functional Genomic, Lyon Catholic University, France
      • 2021 - 2022, Cell Signaling, Lyon Catholic University, France
      • 2021 - 2022, Biologie Structurale et, Lyon Catholic University, France
      • 2021 - 2022, Physiology, Reproduction, Lyon Catholic University, France
      • 2014 - 2015, Active Substances Pharmacology, Université Claude Bernard Lyon 1, France
      • 2013 - 2015, General and Molecular Pharmacology, Université Claude Bernard Lyon 1, France
      • 2010 - 2013, Health and Biology lesson, INSA Lyon, France
  • Awards and distinctions
    • 2017, Post-doctoral Fellowship, Montreal Diabetes Research Center (MDRC), Canada
    • 2016, Allocation exceptionnelle de la Société Francophone du Diabète (SFD), Société Francophone du Diabète, France
    • 2010 - 2013, PhD Fellowship, Ministère de l'Enseignement Supérieur, de la Recherche et de l'Innovation (MESRI), France
  • Certificates and training
    • 2025 Principle and Applications of Next Generation Sequencing methods, Biosciences & Co, France
    • Since 2024 BioMérieux, France
    • 2019 - 2024 Renouvellement Qualification aux fonctions de Maître de Conférence en section 66, Ministère de l'Enseignement Supérieur, de la Recherche et de l'Innovation (MESRI), France
    • 2019 - 2024 Renouvellement Qualification aux fonctions de Maître de Conférences en section CNU 86, Ministère de l'Enseignement Supérieur, de la Recherche et de l'Innovation (MESRI), France
    • 2015 - 2020 Qualifications aux fonctions de Maître de Conférence en section CNU 87 “Sciences biologiques fondamentales et cliniques”: N°15287250178, Ministère de l'Enseignement Supérieur, de la Recherche et de l'Innovation (MESRI), France
    • 2015 - 2020 Qualifications aux fonctions de Maître de conférences en section CNU 65 “Biologie Cellulaire”: N°15265250178, Ministère de l'Enseignement Supérieur, de la Recherche et de l'Innovation (MESRI), France
    • 2014 - 2019 Qualifications aux fonctions de Maître de conférences en section CNU 64 “Biochimie et Biologie Moléculaire”: N°14264250178, Ministère de l'Enseignement Supérieur, de la Recherche et de l'Innovation (MESRI), France
    • 2014 - 2019 Qualifications aux fonctions de Maître de conférences en section CNU 66 “Physiologie”: N°14266250178, Ministère de l'Enseignement Supérieur, de la Recherche et de l'Innovation (MESRI), France
    • 2014 - 2019 Qualifications aux fonctions de Maître de conférences en section CNU 86 “Sciences du médicament et des autres produits de santé”: N°14286250178, Ministère de l'Enseignement Supérieur, de la Recherche et de l'Innovation (MESRI), France
    • Since 2012 Autorisation Individuelle d’expérimenter sur animaux vivants (souris, rat) (N°692661241), Ministère de l'agriculture, de l'agroalimentaire et de la forêt, France
    • Since 2011 « Expérimentation Biologique » Niveau 1 – Ethique et bonnes pratiques pour les responsables de protocoles sur animaux vivants – Agréé par le Ministère de l’agriculture et de la pêche, Ecole Nationale Vétérinaire de Lyon (Vet-Agro Sup), France
  • Languages
    • English - Able to teach