
Brice Lagrange
Maître de conférences de l'UCLy
blagrange@univ-catholyon.fr
Campus Lyon - Saint Paul
10 Place des archives 69002 Lyon
10 Place des archives 69002 Lyon
Informations complémentaires
- Discipline (CNU) : 64. Biochimie et biologie moléculaire
- ORCID : 0000-0002-4131-5995
Domaines de recherche
Biologie cellulaireDomaines d'enseignement
Immunologie PhysiologiePrésentation
Brice Lagrange a un titre de PhD en Biologie Moléculaire et Cellulaire de l’Université de Bourgogne. Il est enseignant-chercheur en biologie cellulaire et immunologie au sein de l’unité de recherche CONFLUENCE : Sciences et Humanités de l’Université Catholique de Lyon. Ses travaux portent sur la compréhension des mécanismes moléculaires induits par la cytokine IFN-g à l’origine de la mort des cellules tumorales. Il enseigne également l’immunologie et la physiologie humaine à l’ESTBB.
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Chapitres
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Chapitres d'ouvrages
- WALLET, Pierre, LAGRANGE, Brice, HENRY, Thomas (2016). «Francisella Inflammasomes: Integrated Responses to a Cytosolic Stealth Bacterium». In : Steffen Backert (dir.), Inflammasome Signaling and Bacterial Infections, coll. Current Topics in Microbiology and Immunology. Springer Publishing, 229-256. [+]
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Chapitres d'ouvrages
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Articles
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Articles dans des revues à comité de lecture
- VALEVA, Stanimira V, DEGABRIEL, Manon, MICHAL, Fanny, GAY, Gabrielle, ROHDE, John R, RANDOW, Felix, LAGRANGE, Brice, HENRY, Thomas (2023). «Comparative study of GBP recruitment on two cytosol-dwelling pathogens, and highlights differences in GBP repertoire and in GBP1 motif requirements». Foodborne pathogens and disease, 81, ftad005. [+]
- NIU, Tingting, DE ROSNY, Charlotte, CHAUTARD, Séverine, REY, Amaury, PATOLI, Danish, GROSLAMBERT, Marine, COSSON, Camille, LAGRANGE, Brice, ZHANG, Zhirong, VISVIKIS, Orane, HACOT, Sabine, HOLOGNE, Maggy, WALKER, Olivier, WONG, Jeimin, WANG, Ping, RICCI, Roméo, HENRY, Thomas, BOYER, Laurent, PETRILLI, Virginie, PY, Bénédicte F. (2021). «NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly». Nature Communications, 12, 1. [+]
- WANDEL, Michal P., KIM, Bae-Hoon, PARK, Eui-Soon, BOYLE, Keith B., NAYAK, Komal, LAGRANGE, Brice, HEROD, Adrian, HENRY, Thomas, ZILBAUER, Matthias, ROHDE, John, MACMICKING, John D., RANDOW, Felix (2020). «Guanylate-binding proteins convert cytosolic bacteria into caspase-4 signaling platforms». Nature immunology, 21, 8, 880-891. [+]
- EREN, Elif, PLANÈS, Rémi, BAGAYOKO, Salimata, BORDIGNON, Pierre-Jean, CHAOUI, Karima, HESSEL, Audrey, SANTONI, Karin, PINILLA, Miriam, LAGRANGE, Brice, BURLET-SCHILTZ, Odile, HOWARD, Jonathan C, HENRY, Thomas, YAMAMOTO, Masahiro, MEUNIER, Etienne (2020). «Irgm2 and Gate-16 cooperatively dampen Gram-negative bacteria-induced caspase-11 response». EMBO reports, 21, 11, e50829. [+]
- BENAOUDIA, Sacha, MARTIN, Amandine, PUIG GAMEZ, Marta, GAY, Gabrielle, LAGRANGE, Brice, CORNUT, Maxence, KRASNYKOV, Kyrylo, CLAUDE, Jean-Baptiste, BOURGEOIS, Cyril F, HUGHES, Sandrine, GILLET, Benjamin, ALLATIF, Omran, CORBIN, Antoine, RICCI, Romeo, HENRY, Thomas (2019). «A genome-wide screen identifies IRF2 as a key regulator of caspase-4 in human cells». EMBO reports, 20, 9, e48235. [+]
- LAGRANGE, Brice, BENAOUDIA, Sacha, WALLET, Pierre, MAGNOTTI, Flora, PROVOST, Angelina, MICHAL, Fanny, MARTIN, Amandine, DI LORENZO, Flaviana, PY, Bénédicte F., MOLINARO, Antonio, HENRY, Thomas (2018). «Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11». Nature Communications, 9, 1, art. 242. [+]
- JAMILLOUX, Yvan, LAGRANGE, Brice, DI MICCO, Antonia, BOURDONNAY, Emilie, PROVOST, Angélina, TALLANT, Rémy, HENRY, Thomas, MARTINON, Fabio (2018). «A proximity-dependent biotinylation (BioID) approach flags the p62/sequestosome-1 protein as a caspase-1 substrate». Journal of Biological Chemistry, 293, 32, 12563-12575. [+]
- SANTOS, José Carlos, DICK, Mathias S, LAGRANGE, Brice, DEGRANDI, Daniel, PFEFFER, Klaus, YAMAMOTO, Masahiro, MEUNIER, Etienne, PELCZAR, Pawel, HENRY, Thomas, BROZ, Petr (2018). «targets host guanylate-binding proteins to the bacterial outer membrane for non-canonical inflammasome activation». The EMBO Journal, 37, 6. [+]
- WALLET, Pierre, MONACK, Denise M., BENAOUDIA, Sacha, MOSNIER, Amandine, LAGRANGE, Brice, MARTIN, Amandine, LINDGREN, Helena, GOLOVLIOV, Igor, MICHAL, Fanny, BASSO, Pauline, DJEBALI, Sophia, PROVOST, Angelina, ALLATIF, Omran, MEUNIER, Etienne, BROZ, Petr, YAMAMOTO, Masahiro, PY, Bénédicte F., FAUDRY, Eric, SJÖSTEDT, Anders, HENRY, Thomas (2017). «IFN-? extends the immune functions of Guanylate Binding Proteins to inflammasome-independent antibacterial activities during Francisella novicida infection». PLoS Pathogens, 13, 10, e1006630. [+]
- BOXIO, Rachel, WARTELLE, Julien, NAWROCKI-RABY, Béatrice, LAGRANGE, Brice, MALLERET, Laurette, HIRCHE, Timothee, TAGGART, Clifford, PACHECO, Yves, DEVOUASSOUX, Gilles, BENTAHER, Abderrazzaq (2016). «Neutrophil elastase cleaves epithelial cadherin in acutely injured lung epithelium». Respiratory research, 17, 1, art. 129. [+]
- WALLET, Pierre, LAGRANGE, Brice, HENRY, Thomas (2015). «Les guanylate binding proteins : de nouveaux acteurs de l’immunité antibactérienne du cytosol des cellules hôtes». Médecine sciences (M/S), 31, 6-7, 600-603. [+]
- LARGEOT, Anne, PAGGETTI, Jérôme, BROSÉUS, Julien, AUCAGNE, Romain, LAGRANGE, Brice, MARTIN, Romain Z., BERTHELET, Jean, QUÉRÉ, Ronan, LUCCHI, Géraldine, DUCOROY, Patrick, BASTIE, Jean-Noël, DELVA, Laurent (2013). «Symplekin, a polyadenylation factor, prevents MOZ and MLL activity on HOXA9 in hematopoietic cells». Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1833, 12, 3054-3063. [+]
- LAGRANGE, Brice, MARTIN, Romain Z., DROIN, Nathalie, AUCAGNE, Romain, PAGGETTI, Jérôme, LARGEOT, Anne, ITZYKSON, Raphaël, SOLARY, Eric, DELVA, Laurent, BASTIE, Jean-Noël (2013). «A role for miR-142-3p in colony-stimulating factor 1-induced monocyte differentiation into macrophages». Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1833, 8, 1936-1946. [+]
- LAGRANGE, Brice, MARTIN, Romain Z., DROIN, Nathalie, SOLARY, Éric, BASTIE, Jean-Noël, DELVA, Laurent (2013). «MiR-142-3p et leucémogenèse». Médecine sciences (M/S), 29, 6-7, 574-576. [+]
- CARTIER, Jessy, BERTHELET, Jean, MARIVIN, Arthur, GEMBLE, Simon, EDMOND, Valérie, PLENCHETTE, Stéphanie, LAGRANGE, Brice, HAMMANN, Arlette, DUPOUX, Alban, DELVA, Laurent, EYMIN, Béatrice, SOLARY, Eric, DUBREZ, Laurence (2011). «Cellular Inhibitor of Apoptosis Protein-1 (cIAP1) Can Regulate E2F1 Transcription Factor-mediated Control of Cyclin Transcription». Journal of Biological Chemistry, 286, 30, 26406-26417. [+]
- AUCAGNE, Romain, DROIN, Nathalie, PAGGETTI, Jérôme, LAGRANGE, Brice, LARGEOT, Anne, HAMMANN, Arlette, BATAILLE, Amandine, MARTIN, Laurent, YAN, Kai-Ping, FENAUX, Pierre, LOSSON, Régine, SOLARY, Eric, BASTIE, Jean-Noël, DELVA, Laurent (2011). «Transcription intermediary factor 1? is a tumor suppressor in mouse and human chronic myelomonocytic leukemia». The Journal of Clinical Investigation, 121, 6, 2361-2370. [+]
- PAGGETTI, J, LARGEOT, A, AUCAGNE, R, JACQUEL, A, LAGRANGE, Brice, YANG, X-J, SOLARY, E, BASTIE, J-N, DELVA, L (2010). «Crosstalk between leukemia-associated proteins MOZ and MLL regulates HOX gene expression in human cord blood CD34+ cells». Oncogene, 29, 36, 5019-5031. [+]
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Articles dans des revues à comité de lecture
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Parcours universitaire
- 2011 Doctorat en Sciences de la vie, Université de Bourgogne, France
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Enseignements
- Depuis 2020 Immunité innée, UCLy, France
- Depuis 2019 Immunologie, UCLy, France
- Depuis 2019 Immunologie, UCLy, France
- Depuis 2019 Physiologie et Biologie Humaine, UCLy, France
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Langues
- Anglais