Thanh Nhat Pham

Associate Professor

Campus Lyon - Saint Paul
10 Place des archives 69002 Lyon


  • Member of Biosciences, technologies, ethics research team Lyon Catholic University
  • Teacher-researcher, ESTBB Lyon Catholic University

Further information

Research areas

Biomass valorization Bioconversion Composé bioactif Biological evaluation Drug design

Teaching areas

General chemistry Biochemistry organic chemistry analytical chemistry Biotechnology


Thanh-Nhat Pham obtained his Doctor of Pharmacy degree from University of Medicine and Pharmacy of Ho Chi Minh city (Vietnam; 2007-2012). He then studied a Master of Pharmaceutical Sciences at University of Lyon (France; 2012-2013), and a PhD in Life and Health Sciences at University of Bourgogne Franche-Comté (France; 2013-2016). His PhD work was on the research of new arginase inhibitors from natural sources and hemisynthesis, under direction of Prof. Corine Girard. He was Assistant Professor in Biochemistry and Medicinal Chemistry at Faculty of Pharmacy of Limoges (France; 2016-2017), where he worked with Prof. Bertrand Liagre on the evaluation of anticancer potentials of arginase inhibitors. Then, he joined the Faculty of Pharmacy, University of Picardie Jules Verne, Amiens (France; 2017-2018) as Assistant Professor in Medicinal Chemistry, and worked with Prof. Pascal Sonnet on the synthesis of siderophore-antimicrobial conjugates. He has been working as Associate Professor at Biology-Biochemistry-Biotechnologies School of the Catholic University of Lyon (France) since 2018. His research interests focus on design, bio-synthesis and biological evaluation of new bioactive compounds from natural sources.
  • Chapters
    • Chapters in proceedings of colloquiums / conferences / seminars / congresses
      • Pham, Thanh Nhat, Guglielmetti, Anne-Sophie, Fimbel, Stéphane, Demougeot, Céline, Girard-Thernier, Corine. Arginase inhibitory activity of several natural polyphenols using a novel in vitro test on purified arginase. In : 62nd International Congress and Annual Meeting of the Society of Medicinal Plant and Natural Product Research, Planta Medica, 2014, pp. P1L9. 10.1055/s-0034-1394667  [+]
  • Articles
    • Articles in peer-reviewed journals
      • Roberto Da Silva, Edson, Abel Alfredo Dos Santos Simone Come, Júlio, Brogi, Simone, Calderone, Vincenzo, Chemi, Giulia, Campiani, Giuseppe, Maria Ferrreira De Sousa Oliveira, Trícia, Pham, Thanh Nhat, Pudlo, Marc, Girard, Corine, Do Carmo Maquiaveli, Claudia. Cinnamides Target Leishmania amazonensis Arginase Selectively [online]. Molecules, Switzerland, 2020, no. 22, vol. 25, pp. 5271. 10.3390/molecules25225271  [+]
      • Pham, Thanh Nhat, Loupias, Pauline, Dassonville-Klimpt, Alexandra, Sonnet, Pascal. Drug delivery systems designed to overcome antimicrobial resistance [online]. Medicinal research reviews, United States of America, 2019, no. 6, vol. 39, pp. 2343-2396. 10.1002/med.21588  [+]
      • Pham, Thanh Nhat, Liagre, Bertrand, Girard-Thernier, Corine, Demougeot, Céline. Research of novel anticancer agents targeting arginase inhibition [online]. Drug Discovery Today , Great Britain, 2018, no. 4, vol. 23, pp. 871-878. 10.1016/j.drudis.2018.01.046  [+]
      • Bordage, Simone, Pham, Thanh Nhat, Zedet, Andy, Gugglielmetti, Anne-Sophie, Demougeot, Céline, Girard-Thernier, Corine. Investigation of mammal arginase inhibitory properties of natural ubiquitous polyphenols by using an optimized colorimetric microplate assay [online]. Planta Medica, Germany, 2017, no. 7, vol. 83, pp. 647-653. 10.1055/s-0042-118711  [+]
      • Pham, Thanh Nhat, Bordage, Simone, Pudlo, Marc, Demougeot, Céline, Thai, Khac-Minh, Girard-Thernier, Corine. Cinnamide derivatives as Mammals Arginase Inhibitors: Design, Synthesis, Molecular Docking and Biological Evaluation [online]. International Journal of Molecular Sciences, Switzerland, 2016, no. 10, vol. 17, pp. 1656. 10.3390/ijms17101656  [+]
      • Girard-Thernier, Corine, Pham, Thanh Nhat, Demougeot, Céline. The Promise of Plant-derived Substances as Inhibitors of Arginase [online]. Mini-Reviews in Medicinal Chemistry, Netherlands (The), 2015, no. 10, vol. 15, pp. 798-808. 10.2174/1389557515666150511153852  [+]
  • Communications (conferences, seminars, study days)
    • Pham, Thanh Nhat, Trinh, Duc-Thu, Bordage, Simone, Demougeot, Céline, Pudlo, Marc, Thai, Khac-Minh, Girard-Thernier, Corine. Arginase Inhibitors: from chlorogenic acid to cinnamides (Poster). In : 9th Joint Natural Products Conference 2016, The American Society of Pharmacognosy, the Society for Medicinal Plant and Natural Product Research (GA), the Phytochemical Society of Europe (PSE), Società Italiana di Fitochimica (SIF), Association Francophone pour l’Enseignement et la Recherche en Pharmacognosie (AFERP), and the Japanese Society of Pharmacognosy (JSP), Copenhague, Denmark, 2016.
    • Pham, Thanh Nhat, Trinh, Duc-Thu, Bordage, Simone, Demougeot, Céline, Pudlo, Marc, Thai, Khac-Minh, Girard-Thernier, Corine. Synthèse, docking moléculaire et évaluation biologique de dérivés cinnamides à potentialités inhibitrices d’arginase mammifère. In : 22e Forum des jeunes chercheurs ED Environnement-Santé, Forum des jeunes chercheurs ED Environnement-Santé UBFC, Besançon, France, 2016.
    • Pham, Thanh Nhat, Bordage, Simone, Zedet, Andy, Gugglielmetti, Anne-Sophie, Nappey, Maude, Thai, Khac-Minh, Demougeot, Céline, Girard-Thernier, Corine. Evaluations in vitro et in silico de l’activité inhibitrice de polyphénols naturels sur l’enzyme arginase. In : Journée scientifique annuelle de la SFR FED, Besançon, France, 2016.
    • Pham, Thanh Nhat, Bordage, Simone, Thai, Khac-Minh, Demougeot, Céline, Girard-Thernier, Corine. Cinnamides as potential arginase inhibitors (Poster). In : 7th International conference on Polyphenols and Health, Royal Society of Chemistry, Tours, France, 2015.
    • Pham, Thanh Nhat, Nguyen, Thi Thu Ha, Girard-Thernier, Corine, Thai, Khac-Minh, Trinh, Duc-Thu. Molecular docking study of some cinnamide derivatives as bovine arginase I inhibitors (Poster). In : 1st International conference on Pharmacy education and research network of ASEAN, ASEAN pharmacy schools, Bangkok, Thailand, 2015.
    • Pham, Thanh Nhat, Trinh, Duc-Thu, Bordage, Simone, Demougeot, Céline, Pudlo, Marc, Thai, Khac-Minh, Girard-Thernier, Corine. Cinnamides as potential arginase inhibitors. In : 2nd International symposium AFERP-STOLON, Lyon, France, 2015.
    • Pham, Thanh Nhat, Girard-Thernier, Corine. Hemi-synthesis of plant-derived compounds as new arginase inhibitors. In : 1ère Rencontre Franco-Thai NATSAT : Enzymes, Targets for Plant-derived Compounds, PEPITE EA4267, Université de Franche-Comté, Besançon, France, 2015.
  • Coordination of scientific events
    • Membre du comité d’organisation de la journée scientifique des jeunes chercheurs de l’école doctorale Environnement-Santé, University of Bourgogne-Franche-Comté (UBFC), France, 2016
  • Scientific collaborations
    • Participation in other research projects
      • 2020 - 2024, Project coordinator : Recovery of industrial by-products through biotechnological solutions, Val-Indus, led by Lyon Catholic University
      • 2017 - 2018, Post-doc au sein de l'équipe, Université Picardie Jules Verne Amiens (UPJV), France
      • 2016 - 2017, Post-doc au sein de l'équipe, Université de Limoges, France
    • Associate member of research networks / laboratories
      • 2017 - 2018, Enseignant-chercheur, Université Picardie Jules Verne Amiens (UPJV), France
      • 2016 - 2017, Enseignant-chercheur, Université de Limoges, France
      • 2013 - 2016, Research team member, Université de Franche-Comté, France
      • 2013, Research team member in EA4446, ISBP, Université de Lyon, France
  • Stays in foreign laboratories
    • 01/09/2015 - 30/09/2015, Stage de recherche en Thailande, Naresuan University (NU), Thailand
    • 02/06/2014 - 31/07/2014, Stage de recherche au Vietnam, University of Medicine and Pharmacy, Vietnam
  • Academic background
    • 2016 PhD in Life Sciences, Université de Franche-Comté, France
    • 2013 Master in Drug Sciences, Université Claude Bernard Lyon 1, France
    • 2012 Doctor of Pharmacy, University of Medicine and Pharmacy, Vietnam
  • Prizes & distinctions
    • Since 2015 Grand Prize of the "My thesis in 180s" contest, Université de Bourgogne, France
    • 2013 - 2016 Bourse de recherche du MESRI, Université de Franche-Comté, France
    • 2012 - 2013 Bourse de la Région Rhône-Alpes (MIRA), Université de Lyon, France
  • Teachings
    • 2019 Formation des Formateurs, University of Health Sciences, Cambodia
    • Since 2018 , Lyon Catholic University, France
    • 2017 - 2018 Chimie thérapeutique, Université Picardie Jules Verne Amiens (UPJV), France
    • 2016 - 2017 Chimie thérapeutique, Biochimie, Université de Limoges, France
    • 2014 - 2016 , Université de Franche-Comté, France
  • Languages
    • French - Able to teach
    • English - Able to teach