Philip Lawrence

Associate Professor

Campus Lyon - Saint Paul
10 Place des archives 69002 Lyon

Further information

Research areas

Biologie Sciences du vivant Virology Cancer Biology

Teaching areas

Sciences du vivant Biologie Sciences et technologie Virology Cellular Biology Molecular Biology Genetics


I am an Associate Professor (MCF) of Virology at the Université Catholique de Lyon (UCLy) and research scientist at the University Confluence Research Center. I have worked with viruses including HIV, Measles, Ebola and Nipah and specialise in using techniques in molecular virology to investigate the virus replication cycle and interactions between viral and host cell proteins at the molecular level. I am currently working on HBV and the links between infection and liver cancer in West Africa.
  • Chapters
    • Book chapters
      • Lawrence, Philip, Hardy, Isabelle, Hainaut, Pierre, Gormally, Emmanuelle, Caboux, Elodie, Di Donato, Jeanne-Hélène. Ten years of experience in training Biobank Managers at Master level in France. In : Hainaut, P., Vaught, J., Zatloukal, K., Pasterk, M. (Eds.), Biobanking of Human Biospecimens - Lessons from 25 years of Biobanking Experience, Springer International Publishing AG, Switzerland, 2021, pp. 135-151. 10.1007/978-3-030-55901-4_8  [+]
  • Articles
    • Articles in peer-reviewed journals
      • Dolnik, Olga, Volchkova, Valentina A., Escudero-Perez, Beatriz, Lawrence, Philip, Klenk, Hans-Dieter, Volchkov, Viktor E. Shedding of Ebola Virus Surface Glycoprotein Is a Mechanism of Self-regulation of Cellular Cytotoxicity and Has a Direct Effect on Virus Infectivity. Journal of infectious diseases (The) (JID), 2015, no. suppl 2, vol. 212, pp. S322-S328. 10.1093/infdis/jiv268
      • Volchkova, Valentina A., Vorac, Jaroslav, Repiquet-Paire, Laurie, Lawrence, Philip, Volchkov, Viktor E. Ebola Virus GP Gene Polyadenylation Versus RNA Editing. Journal of infectious diseases (The) (JID), 2015, no. suppl 2, vol. 212, pp. S191-S198. 10.1093/infdis/jiv150
      • Yabukarski, Filip, Lawrence, Philip, Tarbouriech, Nicolas, Bourhis, Jean-Marie, Delaforge, Elise, Jensen, Malene Ringkjøbing, Ruigrok, Rob W H, Blackledge, Martin, Volchkov, Viktor, Jamin, Marc. Structure of Nipah virus unassembled nucleoprotein in complex with its viral chaperone. Nature Structural & Molecular Biology, 2014, no. 9, vol. 21, pp. 754-759. 10.1038/nsmb.2868
      • Lawrence, Philip, Escudero-Pérez, Beatriz, Drexler, Jan Felix, Corman, Victor Max, Müller, Marcel A., Drosten, Christian, Volchkov, Viktor. Surface glycoproteins of the recently identified African Henipavirus promote viral entry and cell fusion in a range of human, simian and bat cell lines. Virus Research, 2014, vol. 181, pp. 77-80. 10.1016/j.virusres.2014.01.003
      • Page, Audrey, Volchkova, Valentina a., Reid, Saint patrick, Mateo, Mathieu, Bagnaud-Baule, Audrey, Nemirov, Kirill, Shurtleff, Amy c., Lawrence, Philip, Reynard, Oliver, Ottmann, Michele, Lotteau, Vincent, Biswal, Shyam s., Thimmulappa, Rajesh k., Bavari, Sina, Volchkov, Viktor e. Marburgvirus Hijacks Nrf2-Dependent Pathway by Targeting Nrf2-Negative Regulator Keap1. Cell Reports, 2014, no. 6, vol. 6, pp. 1026-1036. 10.1016/j.celrep.2014.02.027
      • Escudero-Pérez, Beatriz, Volchkova, Valentina A., Dolnik, Olga, Lawrence, Philip, Volchkov, Viktor E. Shed GP of Ebola Virus Triggers Immune Activation and Increased Vascular Permeability. PLoS Pathogens, 2014, no. 11, vol. 10. 10.1371/journal.ppat.1004509
      • Lawrence, Philip, Portran, Didier, Terrasse, Rachel, Palle, Sabine, Olivier, Thomas, Fantini, Jacques, Bourlet, Thomas, Pozzetto, Bruno, Delezay, Olivier. Selective transmigration of monocyte-associated HIV-1 across a human cervical monolayer and its modulation by seminal plasma. AIDS, 2012, no. 7, vol. 26, pp. 785-796. 10.1097/QAD.0b013e328351426e
      • Grigorov, Boyan, Rabilloud, Jessica, Lawrence, Philip, Gerlier, Denis. Rapid Titration of Measles and Other Viruses: Optimization with Determination of Replication Cycle Length. PLoS ONE, 2011, no. 9, vol. 6, pp. e24135. 10.1371/journal.pone.0024135
      • Lawrence, Philip, Berlier, Willy, Delezay, Olivier, Palle, Sabine, Olivier, Thomas, Saoudin, Henia, Mottin, Stéphane, Lucht, Frédéric, Pozzetto, Bruno, Bourlet, Thomas. Construction and tropism characterisation of recombinant viruses exhibiting HIV-1 env gene from seminal strains. Virology, New York, United States of America, 2009, no. 2, vol. 386, pp. 373-379. 10.1016/j.virol.2009.01.028
      • Granados-Gonzalez, Viviana, Piedrahita, Leidy Diana, Martinez-Gutierrez, Marlen, Lawrence, Philip, Saoudin, Henia, Zapata, Ximena, Lucht, Frederic, Pinter, Abraham, Genin, Christian, Urcuqui-Inchima, Silvio, Riffard, Serge. Neutralizing inter-clade cross-reactivity of HIV-1 V1/V2-specific secretory immunoglobulin A in Colombian and French cohorts. AIDS, 2009, no. 16, vol. 23, pp. 2219-2222. 10.1097/QAD.0b013e328329d134
      • Mbida, André Dieudonné, Sosso, Samuel, Flori, Pierre, Saoudin, Henia, Lawrence, Philip, Monny-Lobé, Marcel, Oyono, Yves, Ndzi, Edward, Cappelli, Giulia, Lucht, Frédéric, Pozzetto, Bruno, Oukem-Boyer, Odile Ouwe Missi, Bourlet, Thomas. Measure of Viral Load by Using the Abbott Real-Time HIV-1 Assay on Dried Blood and Plasma Spot Specimens Collected in 2 Rural Dispensaries in Cameroon. JAIDS Journal of Acquired Immune Deficiency Syndromes, 2009, no. 1, vol. 52, pp. 9-16. 10.1097/QAI.0b013e3181aeccbc
      • Lawrence, Philip, Lutz, Marie-France, Saoudin, Henia, Frésard, Anne, Cazorla, Céline, Fascia, Pascal, Pillet, Sylvie, Pozzetto, Bruno, Lucht, Frédéric, Bourlet, Thomas. Analysis of Polymorphism in the Protease and Reverse Transcriptase Genes of HIV Type 1 CRF02-AG Subtypes From Drug-Naive Patients From Saint-Etienne, France. JAIDS Journal of Acquired Immune Deficiency Syndromes, 2006, no. 4, vol. 42, pp. 396-404. 10.1097/01.qai.0000221675.83950.4a
      • Berlier, Willy, Bourlet, Thomas, Lawrence, Philip, Hamzeh, Hind, Lambert, Claude, Genin, Christian, Verrier, Bernard, Dieu-Nosjean, Marie-Caroline, Pozzetto, Bruno, Delézay, Olivier. Selective sequestration of X4 isolates by human genital epithelial cells: Implication for virus tropism selection process during sexual transmission of HIV. Journal of Medical Virology, 2005, no. 4, vol. 77, pp. 465-474. 10.1002/jmv.20478
      • Cremel, Magali, Berlier, Willy, Hamzeh, Hind, Cognasse, Fabrice, Lawrence, Philip, Genin, Christian, Bernengo, Jean-Claude, Lambert, Claude, Dieu-Nosjean, Marie-Caroline, Delézay, Olivier. Characterization of CCL20 secretion by human epithelial vaginal cells: involvement in Langerhans cell precursor attraction. Journal of Leukocyte Biology, 2005, no. 1, vol. 78, pp. 158-166. 10.1189/jlb.0305147  [+]
    • Review articles
      • Lawrence, Philip, Danet, Nicolas, Reynard, Olivier, Volchkova, Valentina, Volchkov, Viktor. Human transmission of Ebola virus. Current Opinion in Virology (COVIRO) , 2017, vol. 22, pp. 51-58. 10.1016/j.coviro.2016.11.013
      • Herfst, Sander, Böhringer, Michael, Karo, Basel, Lawrence, Philip, Lewis, Nicola S, Mina, Michael J, Russell, Charles J, Steel, John, De Swart, Rik L, Menge, Christian. Drivers of airborne human-to-human pathogen transmission. Current Opinion in Virology (COVIRO) , 2017, vol. 22, pp. 22-29. 10.1016/j.coviro.2016.11.006
      • Richard, Mathilde, Knauf, Sascha, Lawrence, Philip, Mather, Alison E, Munster, Vincent J, Müller, Marcel A, Smith, Derek, Kuiken, Thijs. Factors determining human-to-human transmissibility of zoonotic pathogens via contact. Current Opinion in Virology (COVIRO) , 2017, vol. 22, pp. 7-12. 10.1016/j.coviro.2016.11.004
      • Pavot, Vincent, Rochereau, Nicolas, Lawrence, Philip, Girard, Marc P., Genin, Christian, Verrier, Bernard, Paul, Stéphane. Recent progress in HIV vaccines inducing mucosal immune responses. AIDS, 2014, no. 12, vol. 28, pp. 1701-1718. 10.1097/QAD.0000000000000308
      • Benjelloun, F., Lawrence, Philip, Verrier, Bernard, Genin, C., Paul, S. Role of Human Immunodeficiency Virus Type 1 Envelope Structure in the Induction of Broadly Neutralizing Antibodies. Journal of virology, 2012, no. 24, vol. 86, pp. 13152-13163. 10.1128/JVI.01110-12
      • Pozzetto, Bruno, Delezay, O., Hamzeh-Cognasse, H., Lawrence, Philip, Lucht, F., Bourlet, T. Place des microbicides vaginaux dans la prévention de l’infection par le virus de l’immunodéficience humaine. Antibiotiques, 2010, no. 2, vol. 12, pp. 90-99. 10.1016/j.antib.2010.01.005
      • Lawrence, Philip, Zimmer, Aline, Paul, Stéphane. Infection muqueuse par le virus VIH-1: mécanismes, conséquences, perspectives de vaccination. Revue Francophone des Laboratoires, 2009, no. 410, vol. 2009, pp. 45-54. 10.1016/S1773-035X(09)71681-8  [+]
  • Communications (conferences, seminars, study days)
    • Lawrence, Philip. Les diarrhées infectieuses en période épidémique du virus Ebola. In : 1er Colloque scientifique BSF/ESTBB (22 novembre), Biologie Sans Frontières (BSF) - ESTBB, Lyon, France, 2019.
    • Gormally, Emmanuelle, Lawrence, Philip, Hardy, Isabelle. Biobank Management Training for Masters Students – 10 years of experience of vocational training for students and professionals in France and deployment of an online training program in West Africa. In : European Biobank Week 2019, Communications ESBB, Lübeck, Germany, 2019.
    • Gormally, Emmanuelle, Lawrence, Philip, Hardy, Isabelle. Next Generation Biobankers: the French Example, Key note lecture. In : Europe Biobank Week 2018: Biosharing for Scientific Discovery, Antwerp, Belgium, 2018.
  • Scientific collaborations
    • Associate member of research networks / laboratories
      • 2012 - 2018, Research team member, Centre International de Recherche en Infectiologie (CIRI) - UMR 5308, France
  • Editorial activities
    • Development activities of books / journals / articles
      • Reviewer, Current Opinion in Virology (COVIRO) , 2016
  • Expertises, evaluations & consulting
    • 2018, Membre comité scientifique consultatif, ViRelieve, France
  • Academic background
    • 2009 Ph.D. in Cellular & Molecular Biology, Virology, Modélisation in vitro de l’infection et du franchissement de la muqueuse génitale féminine par HIV-1, Université Jean-Monnet Saint-Étienne, France
  • Educational responsibilities and professional experiences
    • 2015 - 2020 , Lyon Catholic University, France
  • Languages
    • English - Able to teach
    • French - Able to teach