Brice Lagrange

Associate Professor

Campus Lyon - Saint Paul
10 Place des archives 69002 Lyon

Further information

  • CNU section: 64. Biochemistry and Molecular Biology

Research areas

Cell Biology

Teaching areas

Immunology Physiology
  • Chapters
    • Book chapters
      • Wallet, Pierre, Lagrange, Brice, Henry, Thomas. Francisella Inflammasomes: Integrated Responses to a Cytosolic Stealth Bacterium. In : Steffen Backert (dir.), Inflammasome Signaling and Bacterial Infections, coll. Current Topics in Microbiology and Immunology, Springer International Publishing AG, 2016, pp. 229-256. 10.1007/978-3-319-41171-2_12  [+]
  • Articles
    • Articles in peer-reviewed journals
      • Wandel, Michal P., Kim, Bae-Hoon, Park, Eui-Soon, Boyle, Keith B., Nayak, Komal, Lagrange, Brice, Herod, Adrian, Henry, Thomas, Zilbauer, Matthias, Rohde, John, Macmicking, John D., Randow, Felix. Guanylate-binding proteins convert cytosolic bacteria into caspase-4 signaling platforms. Nature immunology, United States of America, 2020, no. 8, vol. 21, pp. 880-891. 10.1038/s41590-020-0697-2  [+]
      • Eren, Elif, Planès, Rémi, Bagayoko, Salimata, Bordignon, Pierre-Jean, Chaoui, Karima, Hessel, Audrey, Santoni, Karin, Pinilla, Miriam, Lagrange, Brice, Burlet-Schiltz, Odile, Howard, Jonathan C, Henry, Thomas, Yamamoto, Masahiro, Meunier, Etienne. Irgm2 and Gate-16 cooperatively dampen Gram-negative bacteria-induced caspase-11 response. EMBO reports, Germany, 2020, no. 11, vol. 21, pp. e50829. 10.15252/embr.202050829  [+]
      • Benaoudia, Sacha, Martin, Amandine, Puig Gamez, Marta, Gay, Gabrielle, Lagrange, Brice, Cornut, Maxence, Krasnykov, Kyrylo, Claude, Jean-Baptiste, Bourgeois, Cyril F, Hughes, Sandrine, Gillet, Benjamin, Allatif, Omran, Corbin, Antoine, Ricci, Romeo, Henry, Thomas. A genome-wide screen identifies IRF2 as a key regulator of caspase-4 in human cells. EMBO reports, Germany, 2019, no. 9, vol. 20, pp. e48235. 10.15252/embr.201948235  [+]
      • Lagrange, Brice, Benaoudia, Sacha, Wallet, Pierre, Magnotti, Flora, Provost, Angelina, Michal, Fanny, Martin, Amandine, Di Lorenzo, Flaviana, Py, Bénédicte F., Molinaro, Antonio, Henry, Thomas. Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11. Nature Communications, Great Britain, 2018, no. 1, vol. 9, pp. n°242. 10.1038/s41467-017-02682-y  [+]
      • Jamilloux, Yvan, Lagrange, Brice, Di Micco, Antonia, Bourdonnay, Emilie, Provost, Angélina, Tallant, Rémy, Henry, Thomas, Martinon, Fabio. A proximity-dependent biotinylation (BioID) approach flags the p62/sequestosome-1 protein as a caspase-1 substrate. Journal of Biological Chemistry, 2018, no. 32, vol. 293, pp. 12563-12575. 10.1074/jbc.RA117.000435  [+]
      • Santos, José Carlos, Dick, Mathias S, Lagrange, Brice, Degrandi, Daniel, Pfeffer, Klaus, Yamamoto, Masahiro, Meunier, Etienne, Pelczar, Pawel, Henry, Thomas, Broz, Petr. targets host guanylate-binding proteins to the bacterial outer membrane for non-canonical inflammasome activation [online]. The EMBO Journal, 2018, no. 6, vol. 37. 10.15252/embj.201798089  [+]
      • Wallet, Pierre, Benaoudia, Sacha, Mosnier, Amandine, Lagrange, Brice, Martin, Amandine, Lindgren, Helena, Golovliov, Igor, Michal, Fanny, Basso, Pauline, Djebali, Sophia, Provost, Angelina, Allatif, Omran, Meunier, Etienne, Broz, Petr, Yamamoto, Masahiro, Py, Bénédicte F., Faudry, Eric, Sjöstedt, Anders, Henry, Thomas. IFN-? extends the immune functions of Guanylate Binding Proteins to inflammasome-independent antibacterial activities during Francisella novicida infection. PLoS Pathogens, 2017, no. 10, vol. 13, pp. e1006630. 10.1371/journal.ppat.1006630  [+]
      • Wallet, Pierre, Lagrange, Brice, Henry, Thomas. Les guanylate binding proteins : de nouveaux acteurs de l’immunité antibactérienne du cytosol des cellules hôtes. Médecine sciences (M/S), France, 2015, no. 6-7, vol. 31, pp. 600-603. 10.1051/medsci/20153106009  [+]
      • Largeot, Anne, Paggetti, Jérôme, Broséus, Julien, Aucagne, Romain, Lagrange, Brice, Martin, Romain Z., Berthelet, Jean, Quéré, Ronan, Lucchi, Géraldine, Ducoroy, Patrick, Bastie, Jean-Noël, Delva, Laurent. Symplekin, a polyadenylation factor, prevents MOZ and MLL activity on HOXA9 in hematopoietic cells. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2013, no. 12, vol. 1833, pp. 3054-3063. 10.1016/j.bbamcr.2013.08.013  [+]
      • Lagrange, Brice, Martin, Romain Z., Droin, Nathalie, Aucagne, Romain, Paggetti, Jérôme, Largeot, Anne, Itzykson, Raphaël, Solary, Eric, Delva, Laurent, Bastie, Jean-Noël. A role for miR-142-3p in colony-stimulating factor 1-induced monocyte differentiation into macrophages. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2013, no. 8, vol. 1833, pp. 1936-1946. 10.1016/j.bbamcr.2013.04.007  [+]
      • Lagrange, Brice, Martin, Romain Z., Droin, Nathalie, Solary, Éric, Bastie, Jean-Noël, Delva, Laurent. MiR-142-3p et leucémogenèse. Médecine sciences (M/S), 2013, no. 6-7, vol. 29, pp. 574-576. 10.1051/medsci/2013296007  [+]
      • Cartier, Jessy, Berthelet, Jean, Marivin, Arthur, Gemble, Simon, Edmond, Valérie, Plenchette, Stéphanie, Lagrange, Brice, Hammann, Arlette, Dupoux, Alban, Delva, Laurent, Eymin, Béatrice, Solary, Eric, Dubrez, Laurence. Cellular Inhibitor of Apoptosis Protein-1 (cIAP1) Can Regulate E2F1 Transcription Factor-mediated Control of Cyclin Transcription. Journal of Biological Chemistry, 2011, no. 30, vol. 286, pp. 26406-26417. 10.1074/jbc.M110.191239  [+]
      • Aucagne, Romain, Droin, Nathalie, Paggetti, Jérôme, Lagrange, Brice, Largeot, Anne, Hammann, Arlette, Bataille, Amandine, Martin, Laurent, Yan, Kai-Ping, Fenaux, Pierre, Losson, Régine, Solary, Eric, Bastie, Jean-Noël, Delva, Laurent. Transcription intermediary factor 1? is a tumor suppressor in mouse and human chronic myelomonocytic leukemia. The Journal of Clinical Investigation, 2011, no. 6, vol. 121, pp. 2361-2370. 10.1172/JCI45213  [+]
      • Paggetti, J, Largeot, A, Aucagne, R, Jacquel, A, Lagrange, Brice, Yang, X-J, Solary, E, Bastie, J-N, Delva, L. Crosstalk between leukemia-associated proteins MOZ and MLL regulates HOX gene expression in human cord blood CD34+ cells. Oncogene, 2010, no. 36, vol. 29, pp. 5019-5031. 10.1038/onc.2010.254  [+]
    • Articles in non-peer reviewed journals
      • Boxio, Rachel, Wartelle, Julien, Nawrocki-Raby, Béatrice, Lagrange, Brice, Malleret, Laurette, Hirche, Timothee, Taggart, Clifford, Pacheco, Yves, Devouassoux, Gilles, Bentaher, Abderrazzaq. Neutrophil elastase cleaves epithelial cadherin in acutely injured lung epithelium [online]. Respiratory research, 2016, no. 1, vol. 17, pp. article 129. 10.1186/s12931-016-0449-x  [+]
  • Academic background
    • 2011 Docteur en Sciences de la Vie, Université de Bourgogne, France
  • Teachings
    • Since 2020 Innate immunity, Lyon Catholic University, France
    • Since 2019 Immunologie, Lyon Catholic University, France
    • Since 2019 Immunology, Lyon Catholic University, France
    • Since 2019 Physiologie et Biologie Humaine, Lyon Catholic University, France
  • Languages
    • English