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Philip Lawrence

Professor of UCLy

7. Biosciences, Technologies and Ethics

plawrence@univ-catholyon.fr

Campus Lyon - Saint Paul
10 Place des archives 69002 Lyon

Function

  • Head of the Biosciences, Technologies and Ethics Research Group, UR CONFLUENCE : Sciences et Humanités (EA1598) Lyon Catholic University

Further information

Research areas

Biology Life Sciences Virology Cancer Biology

Teaching areas

Life Sciences Biology Science and technology Virology Cell Biology Molecular Biology Genetics

Presentation

I am a Professor of Virology (Ph.D., HDR) at the Université Catholique de Lyon (UCLy) and research scientist at the University Confluence: Science and Humanities Research Center. I have worked with viruses including HIV, Measles, Ebola and Nipah and specialise in using techniques in molecular virology to investigate the virus replication cycle and interactions between viral and host cell proteins at the molecular level. I am currently working on chronic HBV infection and the links between virus infection and liver cancer in West Africa.
  • Chapters
    • Book chapters
      • LAWRENCE, Philip, HARDY, Isabelle, HAINAUT, Pierre, GORMALLY, Emmanuelle, CABOUX, Elodie, DI DONATO, Jeanne-Hélène (2021). «Ten years of experience in training Biobank Managers at Master level in France». In : Hainaut, P., Vaught, J., Zatloukal, K., Pasterk, M. (dir.), Hainaut, P., Vaught, J., Zatloukal, K., Pasterk, M., Biobanking of Human Biospecimens - Lessons from 25 years of Biobanking Experience. Springer Publishing, 135-151.  [+]
  • Articles
    • Articles in peer-reviewed journals
      • LAWRENCE, Philip, CHABANE, M., ABROUK, Lucie, THIESSON, A., BERTHÉ, D., DIARRA, A.b., BENGALY, K., TRAORÉ, B., KASSOGUÉ, D., DURAND, G., VOEGELE, C., LE CALVEZ-KELM , F., STEENKESTE, N., HAINAUT, Pierre, KOURIBA, Bourema, GORMALLY, Emmanuelle (2023). «First Molecular Characterization of Chronic Hepatitis B Carriers in Timbuktu, Mali». Diagnostics, 13 (3), 375.  [+]
      • ALEJANDRA VÁZQUEZ, C, REIMER, R, LAWRENCE, Philip, WIDERSPICK, L, THUENAUER, R, SCHNEIDER, C, NEIRA, P, OLAL, C, HEUNG, M, NIEMETZ, L, KUCINSKAITE-KODZE, I, REDECKE, L, ESCUDERO-PÉREZ, Beatriz (2022). «Nipah virus infection generates ordered structures in cellulo». Viruses, 7, 14, 1523.  [+]
      • WIDERSPICK, L, ALEJANDRA VÁZQUEZ, C, NIEMETZ, L, HEUNG, M, BENCSIK, A, OLAL, C, HENKEL, C, PFISTER, A, EMANUEL BRUNETTI, J, KUCINSKAITE-KODZE, I, LAWRENCE, Philip, MUÑOZ FONTELA, C, DIEDERICH, S, ESCUDERO-PÉREZ, Beatriz (2022). «Inactivation methods for experimental Nipah virus infection». Viruses, 14 (5), 1052.  [+]
      • DOLNIK, Olga, VOLCHKOVA, Valentina A., ESCUDERO-PEREZ, Beatriz, LAWRENCE, Philip, KLENK, Hans-Dieter, VOLCHKOV, Viktor E. (2015). «Shedding of Ebola Virus Surface Glycoprotein Is a Mechanism of Self-regulation of Cellular Cytotoxicity and Has a Direct Effect on Virus Infectivity». Journal of infectious diseases (The) (JID), 212, suppl 2, S322-S328.  [+]
      • VOLCHKOVA, Valentina A., VORAC, Jaroslav, REPIQUET-PAIRE, Laurie, LAWRENCE, Philip, VOLCHKOV, Viktor E. (2015). «Ebola Virus GP Gene Polyadenylation Versus RNA Editing». Journal of infectious diseases (The) (JID), 212, suppl 2, S191-S198.  [+]
      • ESCUDERO-PÉREZ, Beatriz, KUHN, Jens H., VOLCHKOVA, Valentina A., DOLNIK, Olga, LAWRENCE, Philip, VOLCHKOV, Viktor E. (2014). «Shed GP of Ebola Virus Triggers Immune Activation and Increased Vascular Permeability». PLoS Pathogens, 10, 11.  [+]
      • YABUKARSKI, Filip, LAWRENCE, Philip, TARBOURIECH, Nicolas, BOURHIS, Jean-Marie, DELAFORGE, Elise, JENSEN, Malene Ringkjøbing, RUIGROK, Rob W H, BLACKLEDGE, Martin, VOLCHKOV, Viktor, JAMIN, Marc (2014). «Structure of Nipah virus unassembled nucleoprotein in complex with its viral chaperone». Nature Structural & Molecular Biology, 21, 9, 754-759.  [+]
      • LAWRENCE, Philip, ESCUDERO-PÉREZ, Beatriz, DREXLER, Jan Felix, CORMAN, Victor Max, MÜLLER, Marcel A., DROSTEN, Christian, VOLCHKOV, Viktor (2014). «Surface glycoproteins of the recently identified African Henipavirus promote viral entry and cell fusion in a range of human, simian and bat cell lines». Virus Research, 181, 77-80.  [+]
      • PAGE, Audrey, VOLCHKOVA, Valentina a., REID, Saint patrick, MATEO, Mathieu, BAGNAUD-BAULE, Audrey, NEMIROV, Kirill, SHURTLEFF, Amy c., LAWRENCE, Philip, REYNARD, Oliver, OTTMANN, Michele, LOTTEAU, Vincent, BISWAL, Shyam s., THIMMULAPPA, Rajesh k., BAVARI, Sina, VOLCHKOV, Viktor e. (2014). «Marburgvirus Hijacks Nrf2-Dependent Pathway by Targeting Nrf2-Negative Regulator Keap1». Cell Reports, 6, 6, 1026-1036.  [+]
      • LAWRENCE, Philip, PORTRAN, Didier, TERRASSE, Rachel, PALLE, Sabine, OLIVIER, Thomas, FANTINI, Jacques, BOURLET, Thomas, POZZETTO, Bruno, DELEZAY, Olivier (2012). «Selective transmigration of monocyte-associated HIV-1 across a human cervical monolayer and its modulation by seminal plasma». AIDS, 26, 7, 785-796.  [+]
      • GRIGOROV, Boyan, XIANG, Yan, RABILLOUD, Jessica, LAWRENCE, Philip, GERLIER, Denis (2011). «Rapid Titration of Measles and Other Viruses: Optimization with Determination of Replication Cycle Length». PLoS ONE, 6, 9, e24135.  [+]
      • MBIDA, André Dieudonné, SOSSO, Samuel, FLORI, Pierre, SAOUDIN, Henia, LAWRENCE, Philip, MONNY-LOBÉ, Marcel, OYONO, Yves, NDZI, Edward, CAPPELLI, Giulia, LUCHT, Frédéric, POZZETTO, Bruno, OUKEM-BOYER, Odile Ouwe Missi, BOURLET, Thomas (2009). «Measure of Viral Load by Using the Abbott Real-Time HIV-1 Assay on Dried Blood and Plasma Spot Specimens Collected in 2 Rural Dispensaries in Cameroon». JAIDS Journal of Acquired Immune Deficiency Syndromes, 52, 1, 9-16.  [+]
      • LAWRENCE, Philip, BERLIER, Willy, DELEZAY, Olivier, PALLE, Sabine, OLIVIER, Thomas, SAOUDIN, Henia, MOTTIN, Stéphane, LUCHT, Frédéric, POZZETTO, Bruno, BOURLET, Thomas (2009). «Construction and tropism characterisation of recombinant viruses exhibiting HIV-1 env gene from seminal strains». Virology, 386, 2, 373-379.  [+]
      • GRANADOS-GONZALEZ, Viviana, PIEDRAHITA, Leidy Diana, MARTINEZ-GUTIERREZ, Marlen, LAWRENCE, Philip, SAOUDIN, Henia, ZAPATA, Ximena, LUCHT, Frederic, PINTER, Abraham, GENIN, Christian, URCUQUI-INCHIMA, Silvio, RIFFARD, Serge (2009). «Neutralizing inter-clade cross-reactivity of HIV-1 V1/V2-specific secretory immunoglobulin A in Colombian and French cohorts». AIDS, 23, 16, 2219-2222.  [+]
      • LAWRENCE, Philip, LUTZ, Marie-France, SAOUDIN, Henia, FRÉSARD, Anne, CAZORLA, Céline, FASCIA, Pascal, PILLET, Sylvie, POZZETTO, Bruno, LUCHT, Frédéric, BOURLET, Thomas (2006). «Analysis of Polymorphism in the Protease and Reverse Transcriptase Genes of HIV Type 1 CRF02-AG Subtypes From Drug-Naive Patients From Saint-Etienne, France». JAIDS Journal of Acquired Immune Deficiency Syndromes, 42, 4, 396-404.  [+]
      • BERLIER, Willy, BOURLET, Thomas, LAWRENCE, Philip, HAMZEH, Hind, LAMBERT, Claude, GENIN, Christian, VERRIER, Bernard, DIEU-NOSJEAN, Marie-Caroline, POZZETTO, Bruno, DELÉZAY, Olivier (2005). «Selective sequestration of X4 isolates by human genital epithelial cells: Implication for virus tropism selection process during sexual transmission of HIV». Journal of Medical Virology, 77, 4, 465-474.  [+]
      • CREMEL, Magali, LAWRENCE, Philip, BERLIER, Willy, HAMZEH, Hind, COGNASSE, Fabrice, GENIN, Christian, BERNENGO, Jean-Claude, LAMBERT, Claude, DIEU-NOSJEAN, Marie-Caroline, DELÉZAY, Olivier (2005). «Characterization of CCL20 secretion by human epithelial vaginal cells: involvement in Langerhans cell precursor attraction». Journal of Leukocyte Biology, 78, 1, 158-166.  [+]
    • Review articles
      • PHAM, Thanh Nhat, CAZIER, Elisabeth A., GORMALLY, Emmanuelle, LAWRENCE, Philip (2024). «Valorization of biomass polyphenols as potential tyrosinase inhibitors». Drug Discovery Today, 29, 1, 103843.  [+]
      • LAWRENCE, Philip, HEUNG, Michelle, NAVE, Julia, HENKEL, Christoph, ESCUDERO-PÉREZ, Beatriz (2023). «The natural virome and pandemic potential: Disease X». Current Opinion in Virology (COVIRO), 63, 101377.  [+]
      • HILLAIRE, Marine, LAWRENCE, Philip, LAGRANGE, Brice (2023). «IFN-γ: A Crucial Player in the Fight Against HBV Infection?». Immune Network, 23, 4, e30.  [+]
      • ESCUDERO-PÉREZ, Beatriz, LAWRENCE, Philip, CASTILLO-OLIVARES , Javier (2023). «Immune correlates of protection for SARS-CoV-2, Ebola and Nipah virus infection». Frontiers in Immunology, 14.  [+]
      • ESCUDERO-PÉREZ, Beatriz, LALANDE, Alexandre, MATHIEU, Cyrille, LAWRENCE, Philip (2023). «Host - pathogen interactions influencing zoonotic spillover potential and transmission in humans». Viruses, 15, 3, 599.  [+]
      • LAWRENCE, Philip, RAQUET, Michel (2022). «Covid-19, from an emerging infectious disease to a global pandemic: how biological, ecological and epidemiological factors can influence the emergence of zoonotic pathogens». Revue CONFLUENCE : Sciences & Humanités, 1, 29-57.  [+]
      • LAWRENCE, Philip, ESCUDERO-PÉREZ, Beatriz (2022). «Henipavirus Immune Evasion and Pathogenesis Mechanisms: Lessons Learnt from Natural Infection and Animal Models.». Viruses, 14, 5, 936.  [+]
      • LAWRENCE, Philip, DANET, Nicolas, REYNARD, Olivier, VOLCHKOVA, Valentina, VOLCHKOV, Viktor (2017). «Human transmission of Ebola virus». Current Opinion in Virology (COVIRO), 22, 51-58.  [+]
      • HERFST, Sander, BÖHRINGER, Michael, KARO, Basel, LAWRENCE, Philip, LEWIS, Nicola S, MINA, Michael J, RUSSELL, Charles J, STEEL, John, DE SWART, Rik L, MENGE, Christian (2017). «Drivers of airborne human-to-human pathogen transmission». Current Opinion in Virology (COVIRO), 22, 22-29.  [+]
      • RICHARD, Mathilde, KNAUF, Sascha, LAWRENCE, Philip, MATHER, Alison E, MUNSTER, Vincent J, MÜLLER, Marcel A, SMITH, Derek, KUIKEN, Thijs (2017). «Factors determining human-to-human transmissibility of zoonotic pathogens via contact». Current Opinion in Virology (COVIRO), 22, 7-12.  [+]
      • PAVOT, Vincent, ROCHEREAU, Nicolas, LAWRENCE, Philip, GIRARD, Marc P., GENIN, Christian, VERRIER, Bernard, PAUL, Stéphane (2014). «Recent progress in HIV vaccines inducing mucosal immune responses». AIDS, 28, 12, 1701-1718.  [+]
      • BENJELLOUN, F., LAWRENCE, Philip, VERRIER, Bernard, GENIN, C., PAUL, S. (2012). «Role of Human Immunodeficiency Virus Type 1 Envelope Structure in the Induction of Broadly Neutralizing Antibodies». Journal of virology, 86, 24, 13152-13163.  [+]
      • POZZETTO, Bruno, DELEZAY, O., HAMZEH-COGNASSE, H., LAWRENCE, Philip, LUCHT, F., BOURLET, T. (2010). «Place des microbicides vaginaux dans la prévention de l’infection par le virus de l’immunodéficience humaine». Antibiotiques, 12, 2, 90-99.  [+]
      • LAWRENCE, Philip, ZIMMER, Aline, PAUL, Stéphane (2009). «Infection muqueuse par le virus VIH-1: mécanismes, conséquences, perspectives de vaccination». Revue Francophone des Laboratoires, 2009, 410, 45-54.  [+]
    • Articles in non-peer reviewed journals
      • LAWRENCE, Philip (2018). «Les virus et les frontières». Revue de l’Université Catholique de Lyon, 34, 51-57.
  • Communications (conferences, seminars, study days)
    • SAVARINO, Baptiste, COSSOUD BEATRIX , Paule-Martine, CAZIER, Elisabeth A., GORMALLY, Emmanuelle, LAWRENCE, Philip, PHAM, Thanh Nhat (2023). «Valorisation of polyphenols from industrial black tea waste». XXXI International Conference on Polyphenols - ICP2023, INRAE & Groupe Polyphénols, July 2023, Nantes, France.  [+]
    • LAWRENCE, Philip (2019). «Les diarrhées infectieuses en période épidémique du virus Ebola». 1er Colloque scientifique BSF/ESTBB, Biologie Sans Frontières (BSF) - ESTBB, November 2019, Lyon, France.
    • GORMALLY, Emmanuelle, LAWRENCE, Philip, HARDY, Isabelle (2019). «Biobank Management Training for Masters Students – 10 years of experience of vocational training for students and professionals in France and deployment of an online training program in West Africa», Communications ESBB. European Biobank Week 2019, bbmri-eric, January 2019, Lübeck, Germany.
    • GORMALLY, Emmanuelle, LAWRENCE, Philip, HARDY, Isabelle (2018). «Next Generation Biobankers: the French Example, Key note lecture». Europe Biobank Week 2018: Biosharing for Scientific Discovery, BBMRI-ERIC, ESBB, September 2018, Antwerp, Belgium.
  • Popularization & dissemination of research
    • GORMALLY, Emmanuelle, LAWRENCE, Philip (2019). «Infection chronique au virus de l’hépatite B et cancer hépatocellulaire au Mali – Etiologie et caractérisation moléculaire». Revue de l’Université catholique de Lyon, 35, 35-42.
  • Scientific collaborations
    • Participation in other research projects
      • 2021 - 2023, Project coordinator : Chronic hepatitis B prevalence and liver cancer risk factor caracterisation in Mali, Région Auvergne Rhône-Alpes, in partnership with Centre d'infectiologie Charles Merieux (CICM)
    • Associate member of research networks / laboratories
      • 2012 - 2018, Research team member, Centre International de Recherche en Infectiologie (CIRI) - UMR 5308, France
  • Editorial activities
    • Development activities of books / journals / articles
      • Reviewer, Viruses, 2022
      • Reviewer, Current Opinion in Virology (COVIRO), 2016
  • Expertises, evaluations & consulting
    • 2018, Member of the scientific advisory committee, ViRelieve, France
  • Academic background
    • 2022 Habilitation à Diriger des Recherches, Biology, Virology, Epidémiologie de l’infection par le virus de l’hépatite B et les facteurs de risque pour le développement des hépatocarcinomes cellulaires en Afrique de l’Ouest., Université Claude Bernard Lyon 1, France
    • 2009 Ph.D. in Cellular & Molecular Biology, Virology, Modélisation in vitro de l’infection et du franchissement de la muqueuse génitale féminine par HIV-1., Université Jean-Monnet Saint-Étienne, France
  • Educational responsibilities and professional experiences
    • 2015 - 2020 Head of studies - Master in Biobank Management, Lyon Catholic University, France
  • Languages
    • English - Able to teach
    • French - Able to teach